A pilot study opens the door to the use of Avastin in the curative approach for women with breast cancer
Be tested according to new data from clinical trials phase II Avastin (bevacizumab) drive after surgery for breast cancer in combination with an anthracycline-containing regimens. These results open the way for the use of Avastin as a cure for women with this devastating disease.in the incidence of cardiac side effects usually with this form of chemotherapy. These data support the programs inception phase III adjuvant breast cancer clinic, which includes more than 10,000 patients with early breast cancer. Avastin already offers women with advanced breast cancer (metastatic) the chance to live twice as long without disease progression (1).
Faculty of Medicine and principal investigator of the study E2104. We now know that Avastin in combination with anthracyclines
does not result in rates of cardiac dysfunction in the adjuvant setting and armed with the evidence of impact can be fully validated Avastins a comprehensive Phase III clinical world. Data from the E2104 study have shown that cardiac dysfunction is not a big problem with the combination of Avastin and doxorubicin.SABCS presented in two patients with symptomatic heart failure were reported in either Avastin treatment arms, with which more than 100 patients each. This is in the range expected to occur with the use of anthracycline-based chemotherapy alone.
and recruit patients. The program consists of two large adjuvant studies in patients with HER-2 negative breast cancer: - The E5103 study is to include 4,950 patients and is investigating, with the addition of a
cycle of chemotherapy compared to chemotherapy based on anthracycline anthracyclines respect. - Beatriz study investigating Avastin in combination with standard chemotherapy to chemotherapy alone in patients who are not candidates for 2530 hormone therapy in comparison.In addition, Avastin has been studied in HER-2 breast cancer surgery patients positive position by BETH test. This study will examine the addition of Avastin
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